Researchers from Singapore have in collaboration with researchers in Denmark discovered why cancer drugs stop working and how to make them work again, ultimately improving the treatment for breast cancer, News Wise reports.
Breast cancer can today be treated with drugs but many of these drugs mysteriously stop working after some time, causing a relapse. There are often several molecular pathways that stimulate cancer growth, and most targeted therapies affect only one molecular pathway. Drug resistance often develops because of ‘rescue’ from the other cancer pathway not targeted by the drug treatment. The researchers found a solution – to administer an additional drug that controls the second pathway.
The team led by three professors consists of researchers from the National University Cancer Institute, Singapore, the Cancer Science Institute of Singapore at the National University of Singapore, the Genome Institute of Singapore under the Agency for Science, Technology, and Research, and international research collaborators in Denmark.
Read the full study here